Extensive interference of DNA packaging processes affected by chemotherapeutic drugs.
نویسندگان
چکیده
منابع مشابه
Chemotherapeutic Drugs: DNA Damage and Repair in Glioblastoma
Despite improvements in therapeutic strategies, glioblastoma (GB) remains one of the most lethal cancers. The presence of the blood-brain barrier, the infiltrative nature of the tumor and several resistance mechanisms account for the failure of current treatments. Distinct DNA repair pathways can neutralize the cytotoxicity of chemo- and radio-therapeutic agents, driving resistance and tumor re...
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For past many years, strategies for the preclinical discovery and development of potential anticancer agents have been based largely upon the testing of agents in. selected animals bearing transplantable tumors. The feasibility of implementing combined in vitro/in vivo screening for selective cytotoxicity among panels of human tumor cell lines derived from a broad spectrum of human carcinomas h...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1990
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)55497-1